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Symbol
Name
ID 		Nog
noggin
MGI:104327
Phenotype annotations related to nervous system
!Indicates phenotype varies with strain background.
Darker colors indicate more annotations
Human Phenotypes
Microcephaly
Ectopic posterior pituitary
Optic nerve hypoplasia
Gliosis
Hydrocephalus
Partial agenesis of the corpus callosum
Cerebellar atrophy
Chiari type I malformation
Neuronal loss in central nervous system
Gait ataxia
Bradykinesia
Chorea
Increased intracranial pressure
Delayed speech and language development
Depression
Autism
Personality changes
Dementia
Diminished ability to concentrate
Intellectual disability
Obstructive sleep apnea
Hyperreflexia
Waddling gait
Headache
Global developmental delay
Mild global developmental delay
Seizure
Disease(s) Associated with NOG
craniosynostosis
Huntington's disease
multiple synostoses syndrome 1

Mouse Phenotypes
abnormal neural plate morphology
abnormal neural tube morphology
abnormal neural tube closure
incomplete rostral neuropore closure
open neural tube
spina bifida occulta
kinked neural tube
wavy neural tube
abnormal Rathke's pouch apoptosis
abnormal Rathke's pouch development
absent Rathke's pouch
absent adenohypophysis
absent pituitary infundibular stalk
abnormal pituitary gland development
absent pituitary gland
abnormal pituitary gland physiology
increased cochlear inner hair cell number
increased cochlear outer hair cell number
abnormal forebrain development
abnormal diencephalon morphology
exencephaly
abnormal spinal cord morphology
Availability Mouse Genotype
Nogem1(IMPC)Mbp/Nogem1(IMPC)Mbp
Nogtm1Amc/Nogtm1Amc ! !
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory